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- Work starts on international EUbOPEN chemogenomics effort
- The Centre for Medicines Discovery is launched
- TargetDB: summarising target information
- Crystal structure of SARS-CoV-2 nsp13 (helicase)
- COVID Moonshot – aiming to develop novel small molecule inhibitors targeting SARS-CoV-2
- CMD begins project to revolutionise drug discovery using AI
- Wyatt Yue awarded 2021 Harrington UK Rare Disease Scholar Awards
- Structural Biology identifies new information to accelerate structure-based drug design against Covid-19
- TBXT: A new Target Enabling package for rare disease
- Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers (new paper published)
- Oxford ramps up COVID-19 testing capability
- The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks (new paper published)
- The deubiquitylase USP9X controls ribosomal stalling (new paper published)
- ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex
- Exscientia and the University of Oxford announce partnership to develop treatments for Alzheimer’s disease
- Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva
- Deubiquitinase (DUB) profiling goes high-throughput
- Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva
- Chemogenomics for drug discovery: clinical molecules from open access chemical probes
- Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family
- How can X-ray technology help in Covid research?
- Ubiquitin protease 28, a potential drug target in squamous lung carcinoma
- Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection
- 2021 CMD Student Symposium
- Ubiquitin ligases: guardians of mammalian development
- Fragment Hotspot Mapping to Identify Selectivity-Determining Regions between Related Proteins (new paper published)
- Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase (new paper published)
- Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation (new paper published)
- Congratulations to DPhil student Eva Dalietou
- Congratulations to our DPhil student Amber Truepenny
- The Rainwater grant has been signed
- FOP Friends lab visit
- Research reveals the first molecular understanding of BIRC6 – an essential regulator of cell death
- Research reveals basis for KEAP1-CUL3 E3 ligase assembly and inhibition by CDDO
- Discovery of a chemical probe for CDKL5 demonstrates role in hippocampal CA1 physiology
- The solute carrier SPNS2 recruits PI(4,5)P2 to synergistically regulate transport of sphingosine-1-phosphate
- Latest research at CMD identifies mutations in the BTB domain of KCTD15 that perturb BTB oligomerisation and cause a distinctive frontonasal dysplasia syndrome
- The C2 domain of SHIP1 as an allosteric modulator of phosphatase activity
- Alzheimer’s disease: Protein-protein interaction inhibitors for MSN and CD44
- ASAP Discovery Consortium wins 2023 FASEB Dataworks prize
- Research team receives $25m Cancer Grand Challenges award
- Discovery of Conformationally Constrained ALK2 Inhibitors
- CMD Study Discovers Unexpected Noncovalent Off-Targets of Clinical BTK Inhibitors
- NLRP3 Inflammasome “DUBbed” by UCH-L1, affecting IL-1β production macrophages and microglia
- DPhil Student Matthew Holland Featured in Tatler Magazine after Presenting The Boat Race on BBC One
- DPhil student Donna Di Rienzo is the recipient of an ARUK Thames Valley Pilot Project Award
- CMD study reports first chemical probe for CDKL2
- First structure of amino acid transporter and viral receptor CAT1 determined at the CMD
- Beyond lecanemab: unravelling the future of Alzheimer’s treatments
- Leonidas Koukouflis
- John Davis
- Paul Brennan
- Frank von Delft
- Oleg Fedorov
- Alex Bullock
- Jon Elkins
- Kilian Huber
- Benedikt Kessler
- John Davis
- Cassandra Adams
- Annette von Delft
- Thomas Christott
- Eleanor Williams
- Lucas Martins Ferreira
- Donatella Di Rienzo
- Michael Fairhead
- Lizbe Koekemoer
- Elizabeth MacLean
- Kate Humphrey
- Gavin McKinley
- Dong Wang
- Ashley Pike
- Roslin Adamson
- Jesper Hansen
- Gamma Chi
- Huanyu Li
- Karly Aitmakhanova
- Emma Murphy
- Nathan Wright
- Sneha Anand
- William Bradshaw
- Vittorio Katis
- Joseph Newman
- Charline Giroud
- Philip Charles
- Andreas Damianou
- Roman Fischer
- Svenja Hester
- Hannah Jones
- Darragh O'Brien
- Hannah Scott
- Zhanru Yu
- Katherine England
- Tryfon Zarganis-Tzitzikas
- Tom Grimes
- Zhuoyao Chen
- Melissa Sweeney
- Ashley Ramdass
- Evmorfia Dalietou
- David Sauer
- Brian Marsden
- Milan Fowkes
- Xiangrong Chen
- Eszter Dombi
- Ahmad Alalti
- Daniel Ebner
- Magda Wolna
- Val Millar
- Elena Navarro Guerrero
- Stephanie Hatch
- William Seaton-Burn
- Lap Tse
- Julien Cros
- Emma Mead
- Lynn Wambua
- Eboni Bucknor
- James Henderson
- Margarida Ruas
- Claire Martin
- Maciej Kliszczak
- Katerina Gospodinova
- Laura Ortega Varga
- Gonzalo Vera Namuncura
- Emma Kennedy
- Michael Lowe
- Shania Ibarra
- Bindhu Lakshminarayana
- Ishita Ajith
- Mia Callens
- Amber Truepenny
- Jesus Baltanas Copado
- Jir Sancar
- Anjhu Nair
- Álvaro Vinals Guitart
- Qilong Wu
- Humaira Islam
- Jessica Dixon
- Korvus Wang
- Laurent Brooke
- Lee Harris
- Souvika Bakshi
- Roberta Baronio
- Hannah Dobbs
- Kavya Clement
- Klemensas Simelis
- Alice Condrat
- Beatriz Montes Tan
- Roxanne Lau
- Michael Miller
- Georgina Berridge
- Sarah Flannery
- Aisha Sahi
- James Hulit
- Jasmine Reese
- Pierfrancesco Lapolla
- Simon Davis
- Tianen He
- Yixin Shi
- David Speedman
- Matthew Hankins
- Mingda Ye
- Vijay Kumar
- Lucas Elgueta
- Maria Konstantina Ioannidi
- Mohammed Akbor
- Vassilena Sharlandjeva
- Simeon Draganov
- Anne Sophie Marques
- Felicites Rapon
- Haozhe Xiao
- Jeppe Tranberg-Jensen
- Jiangpeikun Song
- Ludwig Bauer
- Nitisha Gurav
- Srinivasa Adusumalli
- Usha Singh
- Jemima Brimacombe
- Zhanru Yu
- Amelia Henley
- Benedict Wiltshire
- Ewa Wieczorek
- Hadeel Abozenadah
- Hala Kaaki
- Matthew Holland
- Naomi Costello
- Sheenagh Aiken
- William Griffith
- Xinyu Chen
- Zhihe Lei
- Daniel Rand
- Munashe Joy Mudiwa
- Oliver Isaacs
- Tika Malla
- Ethan Chidlow
- Karen Froud
- Ayesha Khan
- Stephanie Wills
- Kate Fieseler
- Ekaterina Kot
- Ines Moskal
- Xiaomin Ni
- Karolina Rygiel
- Jana Malki
- Iolanda Vendrell
- Zhu Liang
- Ilknur Sur Erdem
- Frederik Lassen
- Melissa Marx
- Matteo Ferla
- Tamas Szommer
- Michael Ellis
- Elisabeth Mira Rothweiler
- Lai Cheng
- Rod Chalk
- Anna Li
- Alexandra Maronova
- Antoni Cornish
- Christopher Sluman
- Darren Blase
- Christopher Dodd
- Elvis Ng
- Evie Ferris
- Hannah Bolter
- Helene Bouskela
- Jennifer Telling
- Omar Faruque
- Omar Rivas Rosiles
- Ross Macrae
- Claire McMahon
- Evie Westwood
- Nicholas Croman
- James Metcalfe
- Ievgenii Guzenko
- Lukas Scheibelberger
- Yusi Liu
- Alice Page
- Lenye Dlamini
- Alejandro Gonzalez Orta
- Swapnil Mhaskar
- Mary-Ann Xavier
- Adán Pinto-Fernández
- BRC Translational Science Team
- Cellular Signalling
- Chemical Biology
- Growth Factor Signalling and Ubiquitination
- High Throughput Screening
- Mass Spectrometry for Drug Target Discovery
- Medicinal Chemistry
- Membrane Protein Structural and Chemical Biology
- Protein Crystallography (PX)
- Research Informatics
- The Alzheimer’s Research UK Oxford Drug Discovery Institute (ODDI)