Mutations in CDKL5 (cyclin dependent kinase-like 5) cause a severe neurodevelopmental disorder. A new paper in eLife reports the first chemical probe for CDKL5 that reveals new insights into the roles of CDKL5 in synaptic plasticity and human neuropathology. Acute inhibition reduced post-synaptic function of AMPA-type glutamate receptors and hippocampal term potentiation. The work involves a collaboration between teams at North Carolina, The Francis Crick Institute, Colorado, Ohio State and the Bullock lab at the CMD, Oxford.
Discovery of a chemical probe for CDKL5 demonstrates role in hippocampal CA1 physiology
4 August 2023
Mutations in CDKL5 cause a severe neurodevelopmental disorder. A recent paper in eLife reports the first chemical probe for CDKL5 that reveals new insights into the roles of CDKL5 in synaptic plasticity and human neuropathology.
