Contact information
Michael Ellis
Research Assistant Neuroinflammation
I am working alongside Dr Irina Stefana to investigate the mechanisms underlying the loss of pancreatic beta-cell function seen in type 1 diabetes. The primary focus of this project is investigating the role of the microtubule-associated protein Tau, alongside the various phosphorylated variants, attempting to determine the mechanisms driving this beta-cell failure.
Originally from York, I completed a BSc (Hons) in Medical Sciences and an MSc in Molecular Medicine, both from the University of Leeds. During this time, I investigated the epigenetic regulation of drug-resistant chronic myeloid leukaemia and the associated mechanisms. I joined the DIL Group in August 2019 as a Laboratory Technician working within the Sample Processing Team. I was in this position for nine months before joining the Ludwig Institute for Cancer Research in April 2020 as a Research Assistant. In this position, I investigated how p53 influences the development of pancreatic cancer using a murine model. Finally, I re-joined the Todd-Wicker Group in April 2021 as a Research Assistant.
Recent publications
Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells.
Journal article
Seedat F. et al, (2024), Clin Sci (Lond), 138, 1481 - 1502
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry.
Journal article
Ellis MJ. et al, (2024), Acta Neuropathol, 147
p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer.
Journal article
Miller P. et al, (2023), Cell Death Differ, 30, 1619 - 1635
