William Bradshaw

William received his PhD from the University of Bath, where he worked with Professor Ravi Acharya, studying the structure of proteins found in the S-layer of the "superbug" Clostridioides difficile using X-ray crystallography. He joined the CMD as a postdoctoral researcher in 2018 and works on the structures of a range of proteins that have been implicated in inflammation in the brain in Alzheimer's disease. As part of this work, he has completed five crystallographic fragment screens at Diamond Light Source, determining 256 structures with small molecules bound. He has also determined other structures of proteins implicated in Alzheimer’s in ligand-bound and apo forms, combining these with complementary techniques to improve understanding of their functions, mechanisms and structural dynamics with an aim of working towards small molecule probes.