Contact information
NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ UK
Paul Brennan
PhD, FRSC
Professor of Medicinal Chemistry
- Director – Centre for Medicines Discovery
- Director of Chemistry – Chemical Probes Portal
My research group works at the interface of chemistry and biology to design probes and inhibitors to investigate the intricate workings of human proteins and cells, with particular interest in epigenetic proteins, small GTPases, and dementia. Research interests include medicinal chemistry, fragment- and structure-based drug design, computational chemistry, organic synthesis, and biochemistry. The group is part of the Alzheimer's Research UK Oxford Drug Discovery Institute (ODDI), and Centre for AI in Precision Medicine at the University of Oxford.
More Information
Recent publications
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Drug repurposing in amyotrophic lateral sclerosis (ALS).
Journal article
Carroll E. et al, (2025), Expert Opin Drug Discov, 1 - 18
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Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor.
Journal article
O'Brien DP. et al, (2025), J Proteome Res, 24, 479 - 490
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Identification and characterization of human KALRN mRNA and Kalirin protein isoforms.
Journal article
Mould AW. et al, (2024), Cereb Cortex, 34
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The Chemical Probes Portal - 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research.
Journal article
Sanfelice D. et al, (2024), Nucleic Acids Res
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Covalent Inhibitors of S100A4 Block the Formation of a Pro-Metastasis Non-Muscle Myosin 2A Complex.
Journal article
Giroud C. et al, (2024), J Med Chem, 67, 18943 - 18956