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Publications

Learnt representations of proteins can be used for accurate prediction of small molecule binding sites on experimentally determined and predicted protein structures

Carbery A. et al, (2023)

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.

Syed A. et al, (2023), Nucleic Acids Res

SARS-CoV-2 mutations affect antigen processing by the proteasome to alter CD8+ T cell responses

Wellington D. et al, (2023), Heliyon, e20076 - e20076

Targeted Mass Spectrometry Reveals Interferon-Dependent Eicosanoid and Fatty Acid Alterations in Chronic Myeloid Leukaemia

Scott HC. et al, (2023)

The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.

Fazazi MR. et al, (2023), Brain Res Bull, 202

Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model.

van Leeuwen LL. et al, (2023), Br J Pharmacol

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides.

O'Brien DP. et al, (2023), Mol Cell Proteomics, 22

Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2

Bradshaw WJ. et al, (2023)

Biallelic MED27 variants lead to variable ponto-cerebello-lental degeneration with movement disorders.

Maroofian R. et al, (2023), Brain

Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.

Thompson KN. et al, (2023), Sci Transl Med, 15

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.

Castano A. et al, (2023), Elife, 12

Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells

Athanasiadis P. et al, (2023), iScience, 26

Targeted Mass Spectrometry Reveals Interferon-Dependent Eicosanoid and Fatty Acid Alterations in Chronic Myeloid Leukaemia

Scott HC. et al, (2023)

GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner.

Wang Z. et al, (2023), Cancer Res

Exome-wide evidence of compound heterozygous effects across common phenotypes in the UK Biobank

Lassen FH. et al, (2023)

Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in neighbouring wildtype cells.

Chan DKH. et al, (2023), Cell Death Discov, 9

A comprehensive analysis of the Bencao (herbal) small RNA Atlas reveals novel RNA therapeutics for treating human diseases.

Cao Y. et al, (2023), Sci China Life Sci

USP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins

Gan J. et al, (2023)

Target 2035 - an update on private sector contributions.

Ackloo S. et al, (2023), RSC Med Chem, 14, 1002 - 1011

Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation.

Zenko D. et al, (2023), Sci Adv, 9

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