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Publications

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function.

Oftedal BE. et al, (2021), Commun Biol, 4

The structural basis of fatty acid elongation by the ELOVL elongases

Nie L. et al, (2021), Nature Structural & Molecular Biology, 28, 512 - 520

Exploring protein hotspots by optimized fragment pharmacophores.

Bajusz D. et al, (2021), Nat Commun, 12

Kawasaki Disease Patient Stratification and Pathway Analysis Based on Host Transcriptomic and Proteomic Profiles.

Jackson H. et al, (2021), Int J Mol Sci, 22

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation.

Kilgas S. et al, (2021), Cell Rep, 35

Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms.

Wright CF. et al, (2021), Am J Hum Genet

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Ahern DJ. et al, (2021)

A human importin-β-related disorder: Syndromic thoracic aortic aneurysm caused by bi-allelic loss-of-function variants in IPO8.

Van Gucht I. et al, (2021), Am J Hum Genet

Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation.

Crump NT. et al, (2021), Cell Rep, 35

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity.

Martin JG. et al, (2021), Chembiochem

Assessing the degradation of ancient milk proteins through site-specific deamidation patterns.

Ramsøe A. et al, (2021), Sci Rep, 11

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.

Schuller M. et al, (2021), Sci Adv, 7

Robotic Catalysis: A High‐Throughput Method for Miniature Screening of Mesoporous Metal Oxides**

Potgieter K. et al, (2021), Chemistry–Methods, 1, 192 - 200

Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.

Munshaw S. et al, (2021), J Clin Invest

Structure and activation mechanism of the human liver-type glutaminase GLS2.

Ferreira IM. et al, (2021), Biochimie, 185, 96 - 104

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease.

Pokhilko A. et al, (2021), J Cereb Blood Flow Metab

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.

Mackinnon SR. et al, (2021), ACS Chem Biol

Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics.

Acevedo-Rocha CG. et al, (2021), Nat Commun, 12

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva.

Williams EP. et al, (2021), JCI Insight

Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity.

Doss PMIA. et al, (2021), Cell Rep, 34

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