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Publications

Structure and activation mechanism of the human liver-type glutaminase GLS2.

Ferreira IM. et al, (2021), Biochimie, 185, 96 - 104

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease.

Pokhilko A. et al, (2021), J Cereb Blood Flow Metab

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.

Mackinnon SR. et al, (2021), ACS Chem Biol

Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics.

Acevedo-Rocha CG. et al, (2021), Nat Commun, 12

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva.

Williams EP. et al, (2021), JCI Insight

The deubiquitylase USP9X controls ribosomal stalling.

Clancy A. et al, (2021), J Cell Biol, 220

Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities.

Liang Z. et al, (2021), Cell Commun Signal, 19

TP-MAP - an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data

Feyertag F. and Huber KVM., (2021)

Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva.

Ventura F. et al, (2021), Biomedicines, 9

Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections.

Eyre DW. et al, (2021), BMC Infect Dis, 21

DUB esterase activity further decodes ubiquitin’s enigma

Kessler BM., (2021), Proceedings of the National Academy of Sciences, 118, e2026389118 - e2026389118

Drosophila Sex Peptide controls the assembly of lipid microcarriers in seminal fluid.

Wainwright SM. et al, (2021), Proc Natl Acad Sci U S A, 118

High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging

Chen J. et al, (2021), Science Advances, 7, eabd7819 - eabd7819

ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex.

Williams E. et al, (2021), Biomedicines, 9

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.

Shorrocks A-MK. et al, (2021), Nat Commun, 12

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.

Berger B-T. et al, (2021), Cell Chem Biol

The deubiquitinase TRABID stabilises the K29/K48-specific E3 ubiquitin ligase HECTD1.

Harris LD. et al, (2021), J Biol Chem

Assessment of different screening methods for selecting palaeontological bone samples for peptide sequencing.

Presslee S. et al, (2021), J Proteomics, 230

The duration, dynamics and determinants of SARS-CoV-2 antibody responses in individual healthcare workers.

Lumley SF. et al, (2021), Clin Infect Dis

ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context.

Jones HBL. et al, (2021), Front Chem, 9

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