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Publications

Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

Rodriguez-Berriguete G. et al, (2023), Clinical Cancer Research

Glioblastoma and the search for non-hypothesis driven combination therapeutics in academia

Johanssen T. et al, (2023), Frontiers in Oncology, 12

Simultaneous identification of viruses and viral variants with programmable DNA nanobait.

Bošković F. et al, (2023), Nat Nanotechnol

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.

Gahbauer S. et al, (2023), Proc Natl Acad Sci U S A, 120

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.

Emmenegger M. et al, (2023), iScience

Activity-Based Protein Profiling (ABPP) for Cellular Deubiquitinase (DUB) and Inhibitor Profiling at Deep and High-Throughput Levels.

Jones HBL. et al, (2023), Methods Mol Biol, 2591, 101 - 122

CoPriNet: graph neural networks provide accurate and rapid compound price prediction for molecule prioritisation

Sanchez-Garcia R. et al, (2023), Digital Discovery

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Londregan AT. et al, (2022), J Med Chem

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.

Imprachim N. et al, (2022), Nucleic Acids Res

A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.

Rottner AK. et al, (2022), Nat Genet

The use of a graph database is a complementary approach to a classical similarity search for identifying commercially available fragment merges

Wills S. et al, (2022)

Nilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentation

Kessler BM., (2022), Cellular Immunology, 382, 104638 - 104638

Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities.

Cali E. et al, (2022), Genet Med

Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia.

Washer SJ. et al, (2022), Sci Rep, 12

Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical Implications

Aschenbrenner D. et al, (2022), Journal of Clinical Immunology

COMBATdb: a database for the COVID-19 Multi-Omics Blood ATlas.

Wang D. et al, (2022), Nucleic Acids Res

PointVS: A Machine Learning Scoring Function that Identifies Important Binding Interactions

Scantlebury J. et al, (2022)

Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism.

Cavounidis A. et al, (2022), Mucosal Immunol

Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity.

Collins R. et al, (2022), J Med Chem

Minimalised Three-Dimensional Human Midbrain In Vitro Model for Neurotoxicity Evaluation of DYRK1 Inhibitors

Wan X. et al, (2022)

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