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Publications

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

O'Brien DP. et al, (2022)

LARP1 regulates metabolism and mTORC1 activity in cancer

Chettle J. et al, (2022)

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation

Zhou D. et al, (2022), Nature Communications, 13

Structural basis for antagonism of the ubiquitin ligase BIRC6 by SMAC

Dietz L. et al, (2022)

Fragment Libraries Designed to Be Functionally Diverse Recover Protein Binding Information More Efficiently Than Standard Structurally Diverse Libraries

Carbery A. et al, (2022), Journal of Medicinal Chemistry

High-throughput mass spectrometry maps the sepsis plasma proteome and differences in response

Mi Y. et al, (2022)

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.

Carling PJ. et al, (2022), Autophagy, 1 - 14

Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model.

Merrild NG. et al, (2022), Acta Biomater

Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2.

Gahbauer S. et al, (2022), bioRxiv

T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles.

Céspedes PF. et al, (2022), Nat Commun, 13

Author Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.

Zheng Y. et al, (2022), Nat Commun, 13

Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP).

Smilde BJ. et al, (2022), BMC Musculoskelet Disord, 23

Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins.

Leissing TM. et al, (2022), J Biol Chem

Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism.

Downton P. et al, (2022), Proc Natl Acad Sci U S A, 119

Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.

Govender P. et al, (2022), J Med Chem

Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines.

Wei J. et al, (2022), Nat Med, 28, 1072 - 1082

The effects of endogenously- and exogenously-induced hyperketonemia on exercise performance and adaptation.

Dearlove DJ. et al, (2022), Physiol Rep, 10

Snapshots of actin and tubulin folding inside the TRiC chaperonin.

Kelly JJ. et al, (2022), Nat Struct Mol Biol

SAMPL7 protein-ligand challenge: A community-wide evaluation of computational methods against fragment screening and pose-prediction.

Grosjean H. et al, (2022), J Comput Aided Mol Des

Galaxy workflows for fragment-based virtual screening: a case study on the SARS-CoV-2 main protease.

Bray S. et al, (2022), J Cheminform, 14

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