Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Joseph Newman has solved a crystal structure of the viral helicase at 1.94 Angstrom resolution (PDB: 6ZSL).

Joseph Newman has solved a crystal structure of the viral helicase at 1.94 Angstrom resolution (PDB: 6ZSL). This is a significant improvement on previously published structures of the SARS and MERS helicases. The crystals are highly reproducible and have been submitted to the XChem fragment screening team at Diamond Light source (Alice Douangamath), identifying 50-60 hits out of 600 compounds screened, with several compounds binding in both the nucleotide and RNA binding sites. See the details in Joseph’s open lab notebook.