Contact information
Research groups
Lizbé Koekemoer
Protein Crystallography SRF Coordinator
Born and bred in South Africa, I completed my tertiary education at Stellenbosch university in Organic chemistry and Biochemistry. After completing my Masters I did a stint in the FMCG industry before returning to Stellenbosch for a PhD under the supervision of Prof Erick Strauss on all things CoA biosynthesis related in pathogenic bacteria. This was followed by a Postdoc at the university of Cape town based H3D, Africa’s first integrated drug discovery and development centre founded by Kelly Chibale, in Tuberculosis assay development. During my time at UCT I was fortunate enough be a visiting scientist in Chris Dowson’s laboratory at university of Warwick and I became interested in the application of crystallography and biophysical techniques fin early-stage drug discovery. In 2019 I joined the Structural Genomics Consortium (SGC) Oxford with Frank von Delft and Tobias Krojer to learn SBDD.
I am a Team leader and protein crystallography small research facility (PX-SRF) coordinator at the Centre for Medicines Discovery (CMD) at University of Oxford.
Key publications
A selection of Golden Gate vectors to simplify recombinant protein production in Escherichia coli
Preprint
Fairhead M. et al, (2024)
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.
Journal article
Govender P. et al, (2022), J Med Chem, 65, 6903 - 6925
The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity.
Journal article
Mostert KJ. et al, (2021), ACS Chem Biol, 16, 2401 - 2414
The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting.
Journal article
Wright ND. et al, (2021), Acta Crystallogr D Struct Biol, 77, 62 - 74
Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors
Journal article
Boby ML. et al, (2020)
Recent publications
Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors.
Journal article
Ni X. et al, (2025), Nat Commun, 16
High-throughput crystallographic fragment screening of Zika virus NS3 Helicase.
Preprint
Godoy AS. et al, (2025)
Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography.
Journal article
Grosjean H. et al, (2025), Angew Chem Int Ed Engl, 64
Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.
Journal article
von Delft F. et al, (2025), Res Sq
