Joseph Newman
Group leader – Structural biology of DNA repair
I studied my undergraduate degree in biochemistry in the University of Edinburgh UK from 1998-2002. I did a PhD in structural biology in the lab of Prof David Rice at the University of Sheffield UK from 2003-2007. From 2007-2013 I joined the lab of Prof Rick Lewis at Newcastle University UK where I studied the structure and biophysics of protein complexes involved in central carbon metabolism and biofilm formation in Bacillus subtilis. From 2013 I have been a post-doctoral researcher at the University of Oxford, initially in the Structural Genomics Consortium and now the Centre for Medicines discovery.
My current research interests are the structure and function of DNA repair enzymes including helicases and nucleases. I use structural biology to identify and develop novel starting points for small molecule inhibitors with utility in human health as either cancer therapeutics or antiviral agents.
Recent publications
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The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks
Preprint
Song W. et al, (2024)
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Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing
Preprint
Roddan R. et al, (2024)
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SNM1A is crucial for efficient repair of complex DNA breaks in human cells.
Journal article
Swift LP. et al, (2024), Nat Commun, 15
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Structures of the human transcription factor brachyury offer insights into DNA recognition, and identify small molecule binders for the development of degraders for cancer therapy
Preprint
Newman JA. et al, (2024)
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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
Journal article
Syed A. et al, (2023), Nucleic Acids Res