Michael Fairhead

Postdoctoral Scientist

Protein engineering for Structural Biology

As part of the PX SRF my work mainly involves the development of tools that enable structural biology.

For example developing new plasmids to enable the facile generation of multiple protein constructs. I have also developed workflows to enable the rapid purification of 24-48 constructs in parallel at scales suitable for structural biology. Other work is the utilization of various protein engineering strategies to make targets more tractable for crystallization. Future work will include the rapid generation of binders for structural biology applications.

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.

Ni X. et al, (2025)

Heterologous production, purification and crystallization of 24C-sterol methyltransferase from Candida albicans

Mpontshane NS. et al, (2025)

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