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Assay Development and Screening Team

Team members

Franziska Guenther (Team Leader)

Emma Kennedy (Research Assistant)

Tika Malla (Postdoctoral Research Scientist)

Elisabeth Mira Rothweiler (Postdoctoral Research Scientist)

Lynn Wambua (Postdoctoral Research Scientist)

Munashe Joy Mudiwa (Research Assistant)

William Bradshaw (Postdoctoral Research Scientist)

Karly Aitmakhanova *(DPhil Student/ Research Assistant) 

 

 

TEAM EXPERTISE & TECHNOLOGIES

The Assay Development and Screening team supports early-stage drug discovery by designing and executing robust, high-throughput assays. We screen novel targets against diverse compound libraries, identify and validate hits using orthogonal biochemical approaches, and collaborate closely with our medicinal chemists to refine active compounds. Validated hits are advanced into cell-based assays to investigate their mechanism of action, in partnership with teams across the ODDI.

 

TEAM FOCUS

  • High-throughput, high-quality assay development to support early-stage drug discovery
  • Expertise in biochemical and biophysical, and phenotypic assay platforms
  • Identification and validation of novel hits across a broad range of targets
  • Focus on robust, reproducible workflows tailored for screening and hit selection
  • We screen a diverse and focused collection of libraries of around 250K compounds

 

 OUR TECHNOLOGIES

  • Echo Acoustic Dispenser
  • Formulatrix Tempest Dispenser
  • Pherastar FSX Plate Reader
  • FLIPR Tetra
  • Octet 
  • Cybio Felix liquid handling platform