Membrane Protein Structural and Chemical Biology
Lipid membranes are a chemical and physical barrier which separate the inside and outside of a cell and its organelles. Membrane proteins are therefore required for fundamental import nutrients, export waste, and transmit information within and between cells. Accordingly, these proteins are often mutated in disease and targeted by therapeutic drugs.
Our aim is to examine the biochemistry and determine atomic structures to describe the link between these proteins’ structure and function. To do so we work with scientific colleagues around the globe, developing tools to probe membrane proteins’ roles in human physiology. Through these results we will explain pathophysiology of toxins and mutations, validate these proteins as therapeutic targets, and develop new drugs to treat a variety of diseases.
Our research is funded by:
This research would also not be possible without the assistance of several research facilities, including:
- Diamond Light Source
- electron Bio-Imaging Centre (eBIC)
- Oxford Particle Imaging Centre (OPIC)
- Central Oxford Structural Molecular Imaging Centre (COSMIC)
Finally, our work would indebted to the unwavering support of our parent institutions: