The Centre for Medicines Discovery aims to catalyse the discovery and development of new medicines for patients.
23 July 2021
Professor Frank von Delft is co-founder of the Moonshot project, which is a collaboration of expertise from all over the world. Thanks to the light beam work at Diamond, chemists now know the virus' weak spots and can work on developing a new anti-viral drug.
Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family
20 July 2021
The Bullock group is happy to contribute to this new report by Nonga et al describing the crystal structure-guided design of bisubstrate inhibitors and photoluminescent probes for protein kinases of the PIM Family.
12 April 2021
A key focus of the CMD is the development of small molecule chemical probes to investigate the biology of interesting, disease-relevant protein targets. An often touted benefit of probes is that they accelerate the drug discovery process by providing a starting point for small molecule drugs, but is this really the case? This review seeks to answer that question by describing a number of probes that have gone on to inspire a variety of clinical molecules, and will hopefully encourage drug discoverers to turn to chemical probes for inspiration.
Our next Target Enabling Package is a #TEP for Urea Transporter B (UT-B; #SLC14A1) This TEP shows the structure of UT-B in apo and inhibitor-bound states, & confirms binding of an inhibitor molecule in vitro.
Proteomic Signature of Dysfunctional Circulating Endothelial Colony‐Forming Cells of Young Adults
Tan CMJ. et al, (2021), Journal of the American Heart Association
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
Brand M. et al, (2021), J Med Chem
An observational cohort study on the incidence of SARS-CoV-2 infection and B.1.1.7 variant infection in healthcare workers by antibody and vaccination status.
Lumley SF. et al, (2021), Clin Infect Dis