Joseph Newman
Group leader – Structural biology of DNA repair
I studied my undergraduate degree in biochemistry in the University of Edinburgh UK from 1998-2002. I did a PhD in structural biology in the lab of Prof David Rice at the University of Sheffield UK from 2003-2007. From 2007-2013 I joined the lab of Prof Rick Lewis at Newcastle University UK where I studied the structure and biophysics of protein complexes involved in central carbon metabolism and biofilm formation in Bacillus subtilis. From 2013 I have been a post-doctoral researcher at the University of Oxford, initially in the Structural Genomics Consortium and now the Centre for Medicines discovery.
My current research interests are the structure and function of DNA repair enzymes including helicases and nucleases. I use structural biology to identify and develop novel starting points for small molecule inhibitors with utility in human health as either cancer therapeutics or antiviral agents.
Recent publications
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SNM1A is crucial for efficient repair of complex DNA breaks in human cells.
Journal article
Swift LP. et al, (2024), Nat Commun, 15
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Structures of the human transcription factor brachyury offer insights into DNA recognition, and identify small molecule binders for the development of degraders for cancer therapy
Preprint
Newman JA. et al, (2024)
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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
Journal article
Syed A. et al, (2023), Nucleic Acids Res
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Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.
Journal article
Imprachim N. et al, (2022), Nucleic Acids Res
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Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts
Preprint
Ye M. et al, (2022)