Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.
Journal article
Imprachim N. et al, (2022), Nucleic Acids Res
FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.
Journal article
Rota IA. et al, (2021), Sci Adv, 7
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Journal article
Baddock HT. et al, (2021), Nucleic Acids Res, 49, 9294 - 9309
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Journal article
Yosaatmadja Y. et al, (2021), Nucleic Acids Res, 49, 9310 - 9326
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.
Journal article
Newman JA. et al, (2021), Nat Commun, 12
Structure, Mechanism and Crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase
Preprint
Newman JA. et al, (2021)
SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.
Journal article
Na J. et al, (2021), Cell Death Dis, 12
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Journal article
Yosaatmadja Y. et al, (2021)
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Journal article
Newman JA. et al, (2021), Life Sci Alliance, 4
RecQ helicases in DNA repair and cancer targets.
Journal article
Newman JA. and Gileadi O., (2020), Essays Biochem, 64, 819 - 830
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Journal article
van der Lelij P. et al, (2020), Life Sci Alliance, 3
Molecular basis of the activity of SinR Protein, the master regulator of biofilm formation in bacillus subtilis
Journal article
Newman JA. et al, (2013), Journal of Biological Chemistry, 288, 10766 - 10778
Dissection of the network of interactions that links RNA processing with glycolysis in the bacillus subtilis degradosome
Journal article
Newman JA. et al, (2012), Journal of Molecular Biology, 416, 121 - 136
The bacterial stressosome: A modular system that has been adapted to control secondary messenger signaling
Journal article
Quin MB. et al, (2012), Structure, 20, 350 - 363
RNase Y in Bacillus subtilis: A natively disordered protein that is the functional equivalent of RNase E from Escherichia coli
Journal article
Lehnik-Habrink M. et al, (2011), Journal of Bacteriology, 193, 5431 - 5441
Unusual, dual endo- and exonuclease activity in the degradosome explained by crystal structure analysis of RNase J1
Journal article
Newman JA. et al, (2011), Structure, 19, 1241 - 1251