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Publications

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.

Imprachim N. et al, (2022), Nucleic Acids Res

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts

Ye M. et al, (2022)

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development

Imprachim N. et al, (2022)

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.

Rota IA. et al, (2021), Sci Adv, 7

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.

Baddock HT. et al, (2021), Nucleic Acids Res, 49, 9294 - 9309

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.

Yosaatmadja Y. et al, (2021), Nucleic Acids Res, 49, 9310 - 9326

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.

Newman JA. et al, (2021), Nat Commun, 12

Structure, Mechanism and Crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

Newman JA. et al, (2021)

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.

Na J. et al, (2021), Cell Death Dis, 12

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Yosaatmadja Y. et al, (2021)

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.

Newman JA. et al, (2021), Life Sci Alliance, 4

The SNM1A DNA repair nuclease.

Baddock HT. et al, (2020), DNA Repair (Amst), 95

RecQ helicases in DNA repair and cancer targets.

Newman JA. and Gileadi O., (2020), Essays Biochem, 64, 819 - 830

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.

van der Lelij P. et al, (2020), Life Sci Alliance, 3

Crystal Structure of the Werner’s Syndrome Helicase

Newman JA. et al, (2020)

Molecular basis of the activity of SinR Protein, the master regulator of biofilm formation in bacillus subtilis

Newman JA. et al, (2013), Journal of Biological Chemistry, 288, 10766 - 10778

Dissection of the network of interactions that links RNA processing with glycolysis in the bacillus subtilis degradosome

Newman JA. et al, (2012), Journal of Molecular Biology, 416, 121 - 136

The bacterial stressosome: A modular system that has been adapted to control secondary messenger signaling

Quin MB. et al, (2012), Structure, 20, 350 - 363

RNase Y in Bacillus subtilis: A natively disordered protein that is the functional equivalent of RNase E from Escherichia coli

Lehnik-Habrink M. et al, (2011), Journal of Bacteriology, 193, 5431 - 5441

Unusual, dual endo- and exonuclease activity in the degradosome explained by crystal structure analysis of RNase J1

Newman JA. et al, (2011), Structure, 19, 1241 - 1251

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