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Publications

Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing

Roddan R. et al, (2024)

SNM1A is crucial for efficient repair of complex DNA breaks in human cells.

Swift LP. et al, (2024), Nat Commun, 15

Structures of the human transcription factor brachyury offer insights into DNA recognition, and identify small molecule binders for the development of degraders for cancer therapy

Newman JA. et al, (2024)

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.

Syed A. et al, (2023), Nucleic Acids Res

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.

Imprachim N. et al, (2022), Nucleic Acids Res

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

Ye M. et al, (2022)

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development

Imprachim N. et al, (2022)

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.

Rota IA. et al, (2021), Sci Adv, 7

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.

Baddock HT. et al, (2021), Nucleic Acids Res, 49, 9294 - 9309

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.

Yosaatmadja Y. et al, (2021), Nucleic Acids Res, 49, 9310 - 9326

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.

Newman JA. et al, (2021), Nat Commun, 12

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency

Rota IA. et al, (2021)

Structure, Mechanism and Crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

Newman JA. et al, (2021)

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.

Na J. et al, (2021), Cell Death Dis, 12

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Yosaatmadja Y. et al, (2021)

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.

Newman JA. et al, (2021), Life Sci Alliance, 4

The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting.

Wright ND. et al, (2021), Acta Crystallogr D Struct Biol, 77, 62 - 74

The SNM1A DNA repair nuclease.

Baddock HT. et al, (2020), DNA Repair (Amst), 95

RecQ helicases in DNA repair and cancer targets.

Newman JA. and Gileadi O., (2020), Essays Biochem, 64, 819 - 830

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.

van der Lelij P. et al, (2020), Life Sci Alliance, 3

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