Michael Fairhead
Postdoctoral Scientist
Protein engineering for Structural Biology
As part of the PX SRF my work mainly involves the development of tools that enable structural biology.
For example developing new plasmids to enable the facile generation of multiple protein constructs. I have also developed workflows to enable the rapid purification of 24-48 constructs in parallel at scales suitable for structural biology. Other work is the utilization of various protein engineering strategies to make targets more tractable for crystallization. Future work will include the rapid generation of binders for structural biology applications.
Recent publications
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Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Journal article
Boby ML. et al, (2023), Science, 382
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Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.
Journal article
Godoy AS. et al, (2023), Nucleic Acids Res, 51, 5255 - 5270
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Turning high-throughput structural biology into predictive inhibitor design.
Journal article
Saar KL. et al, (2023), Proc Natl Acad Sci U S A, 120
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Simultaneous identification of viruses and viral variants with programmable DNA nanobait.
Journal article
Bošković F. et al, (2023), Nat Nanotechnol
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Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts
Preprint
Ye M. et al, (2022)