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Publications

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening.

Aschenbrenner JC. et al, (2024)

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response.

Lee AA. et al, (2024)

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals.

Lithgo RM. et al, (2024)

Crystallographic fragment screening delivers diverse chemical scaffolds for Zika virus NS2B-NS3 protease inhibitor development.

Ni X. et al, (2024)

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase.

Godoy AS. et al, (2024)

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

Lithgo R. et al, (2024)

Di-Gluebodies as covalently-rigidified, modular protein assemblies enable simultaneous determination of high-resolution, low-size, cryo-EM structures

Yi G. et al, (2024)

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.

Boby ML. et al, (2023), Science, 382

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.

Godoy AS. et al, (2023), Nucleic Acids Res, 51, 5255 - 5270

Turning high-throughput structural biology into predictive inhibitor design.

Saar KL. et al, (2023), Proc Natl Acad Sci U S A, 120

Simultaneous identification of viruses and viral variants with programmable DNA nanobait.

Bošković F. et al, (2023), Nat Nanotechnol

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

Ye M. et al, (2022)

Simultaneous identification of viruses and SARS-CoV-2 variants with programmable DNA nanobait

Bošković F. et al, (2021)

Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.

Khan Tareque R. et al, (2020), ChemMedChem, 15, 2513 - 2520

Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors

Boby ML. et al, (2020)

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.

Douangamath A. et al, (2020), Nat Commun, 11

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.

Kidd SL. et al, (2020), Chem Sci, 11, 10792 - 10801

IGF1R undergoes active and directed centripetal transport on filopodia upon receptor activation.

Krndija D. and Fairhead M., (2019), Biochem J, 476, 3583 - 3593

Include forthcoming?