BA (Cantab), MA (Cantab), D.Phil. (Oxon)
Associate Professor, Research Informatics; Associate Head of Medical Sciences Division - Digital and Information
- Chair of University Research Computing Board
After completing a D.Phil. within the Iain Campbell lab at the University of Oxford, Brian was awarded a Wellcome Trust Prize Fellowship which he spent at the Abagyan lab at the Scripps Research Institute, La Jolla, USA, devising novel methods for proteins structure superimposition and also implementing high performance compute and storage clusters. He then worked as part of the Computational Chemistry group at BioFocus PLC before settling down at the SGC in Oxford and now the Centre for Medicines Discovery where he continues to be responsible for all aspects of Informatics, IT and structural bioinformatics. He has a particular interest in the development of novel data capture and visualisation methods for structural and chemical biology data.
Since 2013, Brian has split his time with the Kennedy Institute where he and his team are responsible for the provision of IT capabilities as well as effective data management platforms to support the broad range of science within the Institute.
Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical Implications
Aschenbrenner D. et al, (2022), Journal of Clinical Immunology
Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity in the General Population in the United Kingdom.
Vihta KD. et al, (2022), Clin Infect Dis, 75, e329 - e337
SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection.
Wei J. et al, (2022), Nat Commun, 13
Venus: Elucidating the Impact of Amino Acid Variants on Protein Function Beyond Structure Destabilisation.
Ferla MP. et al, (2022), J Mol Biol, 434
Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines.
Wei J. et al, (2022), Nat Med, 28, 1072 - 1082