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The Centre for Medicines Discovery aims to catalyse the discovery and development of new medicines for patients.

LATEST NEWS

CMD 2021 Student Symposium winners

2021 CMD Student Symposium

The 2021 CMD Oxford Student Symposium was a great day full of exciting science from our fantastic students! Special thanks to the student organisers and chairs, for hosting a seamless & exciting day, & congratulations to our prize winners!

Identification of substrates deISGylated by SARS-CoV-2 PLpro

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

From the Sanyal & Kessler labs and collaborators, read about our research findings on the biology of cytokine storms triggered by SARS-CoV-2.

USP28 is required in the survival of LSCCs.

Ubiquitin protease 28, a potential drug target in squamous lung carcinoma

The Behrens (ICR) and Kessler labs show that ubiquitin-specific protease 28 (USP28) is required for the survival of lung squamous cell carcinomas (LSCCs). Using genetic knockout models and a novel small molecule inhibitor of USP28, we demonstrate loss or inhibition of USP28 impairs the growth of LSCCs to a much greater degree than lung adenocarcinomas, associated with a greater degree of loss of c-MYC, c-JUN, and DP63. This work will be of interest to researchers seeking to better understand and treat LSCCs.

Highlights

TREM2 - A TEP for Neuroscience & Neurological Disorders

TREM2: A TEP for Neuroscience & Neurological Disorders

The Target Enabling Package on #TREM2 for #AlzheimersDisease includes investigations on binding modes & functional activity of scFv antibody fragments. In collaboration with @ARUK_ODDI @karolinskainst @thesgconline @KTHresearch @EisaiUS & VivaBiotech. https://doi.org/10.5281/zenodo.5256633

All Highlights

HEALTH INFORMATION

In light of the ongoing high rates of COVID-19 nationally, the continuation of the government’s ‘Plan B’ measures, and the latest guidance for higher education providers issued by the Department for Education, the University has agreed the following measures.

  • Health measures: Face coverings are essential for reducing the spread of COVID-19 and should be worn by all staff and students when moving around University buildings. Members of staff conducting teaching are not required to wear face coverings, to support education delivery. Social distancing is not formally required. However, staff and students are expected to respect each other’s space, using the experience of the last two years.
  • Working arrangements: Staff who are able to work from home are expected to continue doing so where possible. However, the University is fully open for teaching and research, and buildings remain open and should be accessible to all staff. As such, staff are expected to work on site to support in-person teaching, research and wider University operations where necessary.

 Please refer to the University of Oxford Health page for updated health guidance.