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Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

From the Sanyal & Kessler labs and collaborators, read about our research findings on the biology of cytokine storms triggered by SARS-CoV-2.

Ubiquitin protease 28, a potential drug target in squamous lung carcinoma

The Behrens (ICR) and Kessler labs show that ubiquitin-specific protease 28 (USP28) is required for the survival of lung squamous cell carcinomas (LSCCs). Using genetic knockout models and a novel small molecule inhibitor of USP28, we demonstrate loss or inhibition of USP28 impairs the growth of LSCCs to a much greater degree than lung adenocarcinomas, associated with a greater degree of loss of c-MYC, c-JUN, and DP63. This work will be of interest to researchers seeking to better understand and treat LSCCs.

How can X-ray technology help in Covid research?

Professor Frank von Delft is co-founder of the Moonshot project, which is a collaboration of expertise from all over the world. Thanks to the light beam work at Diamond, chemists now know the virus' weak spots and can work on developing a new anti-viral drug.


TREM2: A TEP for Neuroscience & Neurological Disorders

The Target Enabling Package on #TREM2 for #AlzheimersDisease includes investigations on binding modes & functional activity of scFv antibody fragments. In collaboration with @ARUK_ODDI @karolinskainst @thesgconline @KTHresearch @EisaiUS & VivaBiotech.