Covalently constrained 'Di-Gembodies' enable parallel structure solutions by cryo-EM.
Yi G. et al, (2025), Nat Chem Biol
Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain.
Kim Y. et al, (2025), Commun Chem, 8
Heterologous production, purification and crystallization of 24C-sterol methyltransferase fromCandida albicans
Mpontshane NS. et al, (2025)
High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer’s Disease and Cancer
Aitken L. et al, (2025), ACS Chemical Biology
Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Tredup C. et al, (2024), RSC Med Chem
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets.
Schwalm MP. et al, (2024), Nat Commun, 15
High-throughput crystallographic fragment screening of Zika virus NS3 Helicase.
Godoy AS. et al, (2024)
A selection of Golden Gate vectors to simplify recombinant protein production inEscherichia coli
Fairhead M. et al, (2024)
Accelerating Drug Discovery With High-Throughput Crystallographic Fragment Screening and Structural Enablement
Fearon D. et al, (2024), Applied Research
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Boby ML. et al, (2023), Science, 382
Fragment Merging Using a Graph Database Samples Different Catalogue Space than Similarity Search.
Wills S. et al, (2023), J Chem Inf Model, 63, 3423 - 3437