Michael Fairhead PhD
Contact information
Research groups
Michael Fairhead
Postdoctoral Scientist
Protein engineering for Structural Biology
As part of the PX SRF my work mainly involves the development of tools that enable structural biology.
For example developing new plasmids to enable the facile generation of multiple protein constructs. I have also developed workflows to enable the rapid purification of 24-48 constructs in parallel at scales suitable for structural biology. Other work is the utilization of various protein engineering strategies to make targets more tractable for crystallization. Future work will include the rapid generation of binders for structural biology applications.
Recent publications
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Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.
Preprint
Ni X. et al, (2025)
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Heterologous production, purification and crystallization of 24C-sterol methyltransferase fromCandida albicans
Preprint
Mpontshane NS. et al, (2025)
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Crystal structure of Fatty Acid Thioesterase A bound by 129 fragments provides diverse development opportunities
Preprint
Kot E. et al, (2024)
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Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening.
Preprint
Aschenbrenner JC. et al, (2024)
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Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response.
Preprint
Lee AA. et al, (2024)