Enabling and Unlocking Biology in the Open (EUbOPEN)

Introduction

EUbOPEN is a large multinational research project funded by the Innovative Health Initiative of the European Union with a total project budget of €65 million. It is a public-private partnership in which the public partners such as Oxford receive research funding from both the EU and from the private partners. Public and private partners work together to accomplish the goals of the project.

For more information see the EUbOPEN website.

Project Aims

• Develop a chemogenomics compound library of up to 5000 compounds covering 1000 proteins (~1/3 of the current druggable genome).
• Create 100 chemical probes with initial focus on E3 ligases and solute carriers.
• Chemical probes and chemogenomic compounds profiled in more than 20 patient tissue- and blood-derived assays.
• Sustainable open science and pre-competitive infrastructure.

Our role in the project

In Oxford we are making significant contributions to multiple parts of the project:

• Chemogenomics compound libraries covering epigenetic regulatory proteins, solute carriers, proteases and other protein familes (PIs Elkins, Huber).
• Chemical probe discovery for various protein families including E3 ligases and solute carriers (PIs Bullock, Elkins, Huber, Sauer).
• Technology development (PI von Delft)
• Data management (PI Marsden)
• Management, with Dr. Jon Elkins acting as one of the scientific directors of the project.

Consortium

The 22 project partners are spread across Europe and North America, from leading academic labs to pharmaceutical companies, working together to accomplish the ambitious project goals.