Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.

Ni X., Richardson RB., Godoy AS., Ferla MP., Kikawa C., Scheen J., Hannon WW., Capkin E., Lahav N., Balcomb BH., Marples PG., Fairhead M., Wang S., Williams EP., Tomlinson CWE., Aschenbrenner JC., Lithgo RM., Winokan M., Giroud C., Chandran AV., Walsh M., Thompson W., Bloom JD., Barr H., Kirkegaard K., Koekemoer L., Fearon D., Evans MJ., von Delft F.

DOI

10.1101/2024.04.29.591502

Type

Preprint

Publication Date

13/02/2025

Keywords

NS2B-NS3 protease, crystallographic fragment screening, deep mutational scanning, sociable fragments

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