Contact information
Research groups
Xiangrong Chen
Postdoctoral Scientist - Chemical Biology Assays
Recent publications
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Journal article
Chen Z. et al, (2025), Nat Commun, 16
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.
Preprint
Bashore FM. et al, (2024)
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.
Journal article
Ong HW. et al, (2023), ACS Chem Neurosci, 14, 1672 - 1685
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Journal article
Chen X. et al, (2021), Elife, 10
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
Preprint
Chen X. et al, (2020)
