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Publications

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.

Ni X. et al, (2025)

Fragmenstein: predicting protein-ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding-based methodology.

Ferla MP. et al, (2025), J Cheminform, 17

Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency.

Blanco E. et al, (2025), J Exp Med, 222

Crystal structure of Fatty Acid Thioesterase A bound by 129 fragments provides diverse development opportunities

Kot E. et al, (2024)

Enabling equitable and affordable access to novel therapeutics for pandemic preparedness and response via creative intellectual property agreements.

Griffen EJ. et al, (2024), Wellcome Open Res, 9

Turning high-throughput structural biology into predictive inhibitor design.

Saar KL. et al, (2023), Proc Natl Acad Sci U S A, 120

Include forthcoming?