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Publications

Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions.

Ji H. et al, (2023), Cell Chem Biol

Open resources for chemical probes and their implications for future drug discovery.

Balıkçı E. et al, (2023), Expert Opin Drug Discov, 18, 505 - 513

Discovery of a chemical probe to study implications of BPTF bromodomain inhibition in cellular and in vivo experiments.

Martinelli P. et al, (2023), ChemMedChem

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Londregan AT. et al, (2023), J Med Chem, 66, 460 - 472

Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function

Coleman OD. et al, (2023), Chemical Science

Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes.

Rothweiler EM. and Huber KVM., (2023), Methods Mol Biol, 2706, 191 - 200

DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.

Ketley RF. et al, (2022), Cell Rep, 41

Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.

Rothweiler EM. et al, (2022), Biol Chem

A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors

Rothweiler EM. et al, (2022)

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity.

Martin JG. et al, (2021), Chembiochem, 22, 2116 - 2123

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.

Mackinnon SR. et al, (2021), ACS Chem Biol, 16, 586 - 595

TP-MAP - an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data

Feyertag F. and Huber KVM., (2021)

Assays to Characterize the Cellular Pharmacology of a Chemical Probe

Stefaniak J. et al, (2021), DISCOVERY AND UTILITY OF CHEMICAL PROBES IN TARGET DISCOVERY, 16, 247 - 275

Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.

Khan Tareque R. et al, (2020), ChemMedChem, 15, 2513 - 2520

Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

Álvarez-Coiradas E. et al, (2020), Int Immunopharmacol, 89

Include forthcoming?