Drug repurposing in amyotrophic lateral sclerosis (ALS).
Carroll E. et al, (2025), Expert Opin Drug Discov, 1 - 18
Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors.
Bauer LG. et al, (2025), Angew Chem Int Ed Engl, 64
Covalent Inhibitors of KEAP1 with Exquisite Selectivity.
Fejes I. et al, (2024), J Med Chem, 67, 21208 - 21222
Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Tredup C. et al, (2024), RSC Med Chem
Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300
Chen X. et al, (2024), JACS Au
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.
Balıkçı E. et al, (2024), J Med Chem, 67, 7245 - 7259
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Raux B. et al, (2024), Bioorg Med Chem Lett, 98
A live cell PRMT5 NanoBRETT target engagement assay querying competitive and uncompetitive modes of inhibition
Teske KA. et al, (2024), MOLECULAR CANCER THERAPEUTICS, 23
Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.
Digles D. et al, (2024), Front Pharmacol, 15
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions.
Ji H. et al, (2023), Cell Chem Biol, 30, 1478 - 1487.e7
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function.
Coleman OD. et al, (2023), Chem Sci, 14, 7136 - 7146
Open resources for chemical probes and their implications for future drug discovery.
Balıkçı E. et al, (2023), Expert Opin Drug Discov, 18, 505 - 513
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments.
Martinelli P. et al, (2023), ChemMedChem, 18
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
Londregan AT. et al, (2023), J Med Chem, 66, 460 - 472
Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes.
Rothweiler EM. and Huber KVM., (2023), Methods Mol Biol, 2706, 191 - 200
DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.
Ketley RF. et al, (2022), Cell Rep, 41
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.
Rothweiler EM. et al, (2022), Biol Chem, 403, 391 - 402
A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors
Rothweiler EM. et al, (2022)
Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity.
Martin JG. et al, (2021), Chembiochem, 22, 2116 - 2123