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Publications

Open resources for chemical probes and their implications for future drug discovery.

Balıkçı E. et al, (2023), Expert Opin Drug Discov, 18, 505 - 513

Discovery of a chemical probe to study implications of BPTF bromodomain inhibition in cellular and in vivo experiments.

Martinelli P. et al, (2023), ChemMedChem

Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function

Coleman OD. et al, (2023), Chemical Science

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Londregan AT. et al, (2022), J Med Chem

DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.

Ketley RF. et al, (2022), Cell Rep, 41

Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.

Rothweiler EM. et al, (2022), Biol Chem

A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors

Rothweiler EM. et al, (2022)

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity.

Martin JG. et al, (2021), Chembiochem, 22, 2116 - 2123

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.

Mackinnon SR. et al, (2021), ACS Chem Biol, 16, 586 - 595

TP-MAP - an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data

Feyertag F. and Huber KVM., (2021)

Assays to Characterize the Cellular Pharmacology of a Chemical Probe

Stefaniak J. et al, (2021), DISCOVERY AND UTILITY OF CHEMICAL PROBES IN TARGET DISCOVERY, 16, 247 - 275

Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.

Khan Tareque R. et al, (2020), ChemMedChem, 15, 2513 - 2520

Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

Álvarez-Coiradas E. et al, (2020), Int Immunopharmacol, 89