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Chemical Probes for Understudied Kinases: Challenges and Opportunities.

Journal article

Serafim RAM. et al, (2021), J Med Chem

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.

Journal article

Serafim RAM. et al, (2021), J Med Chem

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.

Journal article

Henderson SH. et al, (2021), J Med Chem, 64, 11709 - 11728

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.

Journal article

Berger B-T. et al, (2021), Cell Chem Biol, 28, 686 - 698.e7

Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.

Journal article

Quevedo CE. et al, (2020), Bioorg Med Chem, 28

Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.

Journal article

Henderson SH. et al, (2020), ACS Med Chem Lett, 11, 1620 - 1626

Targeting the Water Network in Cyclin G-Associated Kinase (GAK) with 4-Anilino-quin(az)oline Inhibitors.

Journal article

Asquith CRM. et al, (2020), ChemMedChem, 15, 1200 - 1215

Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer.

Journal article

Scott F. et al, (2020), Bioorg Med Chem Lett, 30

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.

Journal article

Wells C. et al, (2020), ACS Med Chem Lett, 11, 340 - 345

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Journal article

Asquith CRM. et al, (2019), Molecules, 24

Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors.

Journal article

de Toledo I. et al, (2019), J Org Chem, 84, 14187 - 14201

Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.

Journal article

Serafim RAM. et al, (2019), ACS Med Chem Lett, 10, 1266 - 1271

Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.

Journal article

Abdul Azeez KR. et al, (2019), Nat Commun, 10

Crystal structure of human RIOK2 bound to a specific inhibitor.

Journal article

Wang J. et al, (2019), Open Biol, 9

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).

Journal article

Asquith CRM. et al, (2019), J Med Chem, 62, 2830 - 2836

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