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Publications

Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity.

Collins R. et al, (2022), J Med Chem

Chemical Probes for Understudied Kinases: Challenges and Opportunities.

Serafim RAM. et al, (2021), J Med Chem

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.

Serafim RAM. et al, (2021), J Med Chem

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.

Henderson SH. et al, (2021), J Med Chem, 64, 11709 - 11728

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.

Berger B-T. et al, (2021), Cell Chem Biol, 28, 686 - 698.e7

Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.

Quevedo CE. et al, (2020), Bioorg Med Chem, 28

Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.

Henderson SH. et al, (2020), ACS Med Chem Lett, 11, 1620 - 1626

Targeting the Water Network in Cyclin G-Associated Kinase (GAK) with 4-Anilino-quin(az)oline Inhibitors.

Asquith CRM. et al, (2020), ChemMedChem, 15, 1200 - 1215

Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer.

Scott F. et al, (2020), Bioorg Med Chem Lett, 30

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.

Wells C. et al, (2020), ACS Med Chem Lett, 11, 340 - 345

Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships.

Asquith CRM. et al, (2020), ChemMedChem, 15, 26 - 49

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.

Profeta GS. et al, (2019), Sci Rep, 9

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Asquith CRM. et al, (2019), Molecules, 24

Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors.

de Toledo I. et al, (2019), J Org Chem, 84, 14187 - 14201

Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.

Serafim RAM. et al, (2019), ACS Med Chem Lett, 10, 1266 - 1271

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.

Alam MM. et al, (2019), Science, 365

Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.

Abdul Azeez KR. et al, (2019), Nat Commun, 10

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.

Verdonck S. et al, (2019), J Med Chem, 62, 5810 - 5831

Crystal structure of human RIOK2 bound to a specific inhibitor.

Wang J. et al, (2019), Open Biol, 9

Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.

Sorrell FJ. et al, (2019), Biochem J, 476, 1037 - 1051

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