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Publications

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.

Balıkçı E. et al, (2024), J Med Chem

Target 2035 - an update on private sector contributions.

Ackloo S. et al, (2023), RSC Med Chem, 14, 1002 - 1011

Updated protein domain annotation of the PARP protein family sheds new light on biological function.

Suskiewicz MJ. et al, (2023), Nucleic Acids Res

An open source plant kinase chemogenomics set.

Ercoli MF. et al, (2022), Plant Direct, 6

Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity.

Collins R. et al, (2022), J Med Chem, 65, 13705 - 13713

Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.

Scott F. et al, (2022), Bioorg Med Chem Lett, 60

Chemical Probes for Understudied Kinases: Challenges and Opportunities.

Serafim RAM. et al, (2022), J Med Chem, 65, 1132 - 1170

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.

Serafim RAM. et al, (2021), J Med Chem, 64, 13259 - 13278

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.

Henderson SH. et al, (2021), J Med Chem, 64, 11709 - 11728

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.

Berger B-T. et al, (2021), Cell Chem Biol, 28, 686 - 698.e7

Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.

Quevedo CE. et al, (2020), Bioorg Med Chem, 28

Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.

Henderson SH. et al, (2020), ACS Med Chem Lett, 11, 1620 - 1626

Targeting the Water Network in Cyclin G-Associated Kinase (GAK) with 4-Anilino-quin(az)oline Inhibitors.

Asquith CRM. et al, (2020), ChemMedChem, 15, 1200 - 1215

Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer.

Scott F. et al, (2020), Bioorg Med Chem Lett, 30

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.

Wells C. et al, (2020), ACS Med Chem Lett, 11, 340 - 345

Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships.

Asquith CRM. et al, (2020), ChemMedChem, 15, 26 - 49

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.

Profeta GS. et al, (2019), Sci Rep, 9

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Asquith CRM. et al, (2019), Molecules, 24

Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors.

de Toledo I. et al, (2019), J Org Chem, 84, 14187 - 14201

Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.

Serafim RAM. et al, (2019), ACS Med Chem Lett, 10, 1266 - 1271

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