A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.
Rothweiler EM. et al, (2025), Nat Commun, 16
Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors.
Bauer LG. et al, (2025), Angew Chem Int Ed Engl, 64
Covalent Inhibitors of KEAP1 with Exquisite Selectivity.
Fejes I. et al, (2024), J Med Chem, 67, 21208 - 21222
A live cell PRMT5 NanoBRET Target Engagement Assay querying competitive and uncompetitive modes of inhibition
Michaud A. et al, (2024), CANCER RESEARCH, 84
A live cell PRMT5 NanoBRETT target engagement assay querying competitive and uncompetitive modes of inhibition
Teske KA. et al, (2024), MOLECULAR CANCER THERAPEUTICS, 23
Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes.
Rothweiler EM. and Huber KVM., (2023), Methods Mol Biol, 2706, 191 - 200
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.
Rothweiler EM. et al, (2022), Biol Chem, 403, 391 - 402
A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors
Rothweiler EM. et al, (2022)