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Publications

A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1.

Pinkas DM. et al, (2024), Structure

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.

Němec V. et al, (2024), J Med Chem

A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1

Pinkas DM. et al, (2024)

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.

Bashore FM. et al, (2024)

BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.

Miller KA. et al, (2024), J Med Genet, 61, 490 - 501

Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays.

van Veggel L. et al, (2024), ACS Chem Neurosci, 15, 1424 - 1431

Discovery of Conformationally Constrained ALK2 Inhibitors.

González-Álvarez H. et al, (2024), J Med Chem, 67, 4707 - 4725

Author Correction: CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Delconte RB. et al, (2024), Nat Immunol, 25, 371 - 372

PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo.

Brown EJ. et al, (2024), Sci Rep, 14

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2

Bashore FM. et al, (2024), ACS Medicinal Chemistry Letters

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.

Adamson RJ. et al, (2023), Free Radic Biol Med, 204, 215 - 225

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.

Castano A. et al, (2023), Elife, 12

Target 2035 - an update on private sector contributions.

Ackloo S. et al, (2023), RSC Med Chem, 14, 1002 - 1011

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.

Castano A. et al, (2023), bioRxiv

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.

Ong HW. et al, (2023), ACS Chem Neurosci, 14, 1672 - 1685

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly

Adamson RJ. et al, (2023)

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective.

Ong HW. et al, (2023), bioRxiv

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

Chen Z. et al, (2022), Cell Death Differ, 29, 1955 - 1969

Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP).

Smilde BJ. et al, (2022), BMC Musculoskelet Disord, 23

Ubiquitin ligases: guardians of mammalian development.

Cruz Walma DA. et al, (2022), Nat Rev Mol Cell Biol, 23, 350 - 367

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