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Paul Brennan

Contact information


paul.brennan@cmd.ox.ac.uk


Sasha Maronova (preferred contact)
sasha.maronova@cmd.ox.ac.uk


Brennan Group


ORCID ID ORCID


NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ UK

Paul Brennan

PhD, FRSC

Professor of Medicinal Chemistry

  • Director – Centre for Medicines Discovery
  • Director of Chemistry – Chemical Probes Portal

My research group works at the interface of chemistry and biology to design probes and inhibitors to investigate the intricate workings of human proteins and cells, with particular interest in epigenetic proteins, small GTPases, and dementia. Research interests include medicinal chemistry, fragment- and structure-based drug design, computational chemistry, organic synthesis, and biochemistry. The group is part of the Alzheimer's Research UK Oxford Drug Discovery Institute (ODDI), and Centre for AI in Precision Medicine at the University of Oxford.