Contact information
Research groups
David Sauer
Principal Investigator, Membrane Protein Structural and Chemical Biology
David Sauer is a biophysicist focusing on the structure and function of membrane channels and transporters. As group leader at the University of Oxford since 2021, he has been studying the structure and function of membrane proteins for 16 years. David completed his graduate degree studying potassium channel structure and ion selectivity with Youxing Jiang at the University of Texas Southwestern Medical Center. This was followed by postdoctoral training with Da-Neng Wang at New York University School of Medicine. There he described the structure, transport mechanism, and chemical inhibition of SLC13/DASS membrane transporters.
Recent publications
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High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies.
Journal article
Raturi S. et al, (2023), J Vis Exp
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The solute carrier SPNS2 recruits PI(4,5)P2 to synergistically regulate transport of sphingosine-1-phosphate.
Journal article
Tang H. et al, (2023), Mol Cell, 83, 2739 - 2752.e5
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Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
Preprint
Li HZ. et al, (2023)
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Structural basis of ion - substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY.
Journal article
Sauer DB. et al, (2022), Nat Commun, 13
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Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Journal article
Brawley DN. et al, (2022), Nat Chem Biol