Covalently constrained 'Di-Gembodies' enable parallel structure solutions by cryo-EM.
Yi G. et al, (2025), Nat Chem Biol
EAAT3 modulation: A potential novel avenue towards remyelination in multiple sclerosis.
van Veggel L. et al, (2025), Biomed Pharmacother, 186
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2.
Li HZ. et al, (2025), Nat Commun, 16
Structural basis of the mechanism and inhibition of a human ceramide synthase.
Pascoa TC. et al, (2024), Nat Struct Mol Biol
Pho pictures provide powerful perspectives of phosphate importing proteins.
Speedman D. and Sauer DB., (2024), Structure, 32, 849 - 850
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Li HZ. et al, (2024), Nat Commun, 15
Protein binder toolbox for studies of solute carrier transporters.
Gelová Z. et al, (2024), J Mol Biol
Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays.
van Veggel L. et al, (2024), ACS Chem Neurosci, 15, 1424 - 1431
The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Liang Q. et al, (2024), Nat Commun, 15
Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.
Digles D. et al, (2024), Front Pharmacol, 15
Structural basis of the mechanism and inhibition of a human ceramide synthase
Pascoa TC. et al, (2023)
High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies.
Raturi S. et al, (2023), J Vis Exp
The solute carrier SPNS2 recruits PI(4,5)P2 to synergistically regulate transport of sphingosine-1-phosphate.
Tang H. et al, (2023), Mol Cell, 83, 2739 - 2752.e5
Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
Kinz-Thompson C. et al, (2023), PROTEIN SCIENCE, 32