Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography.
Grosjean H. et al, (2025), Angew Chem Int Ed Engl
The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures.
Bradshaw WJ. et al, (2024), Structure, 32, 2337 - 2351.e4
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
Bradshaw WJ. et al, (2024), Structure, 32, 453 - 466.e6
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
Du Y. et al, (2023), J Biol Chem, 299
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2
Bradshaw WJ. et al, (2023)
The structure of the S-layer of Clostridium difficile
Bradshaw WJ. et al, (2018), Journal of Cell Communication and Signaling, 12, 319 - 331
The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile.
Bradshaw WJ. et al, (2017), FEBS J, 284, 4343 - 4357
Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro.
Bradshaw WJ. et al, (2017), FEBS J, 284, 2886 - 2898
Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis
Bradshaw WJ. et al, (2017), Scientific Reports, 7
Molecular features of the sortase enzyme family
Bradshaw WJ. et al, (2015), FEBS Journal, 282, 2097 - 2114
Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide
Bradshaw WJ. et al, (2015), Acta Crystallographica Section F: Structural Biology Communications, 71, 295 - 303
The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile
Bradshaw WJ. et al, (2014), Acta Crystallographica Section D: Biological Crystallography, 70, 1983 - 1993