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A multi-disciplinary Institute within the University of Oxford which focuses upon translational activities to catalyse the discovery of new medicines.
Cellular High Throughput Screening
The HTS facility provides Oxford research scientists and collaborators access to a comprehensive, cost-effective facility for running high throughput cell based small compound and CRISPR screens across a broad range of readouts.
Growth Factor Signalling and Ubiquitination
Our research aims to understand the signalling mechanisms and disease-causing mutations that alter cell growth and differentiation and how these might be targeted by small molecule inhibitors to address devastating rare diseases and cancer.
Chemical Biology
We are interested in the identification of novel drug targets using systems-level approaches such as phenotypic screens and chemical proteomics as well as the structure-based design of highly selective tool compounds for validation of new potential drug targets.
Mass Spectrometry for Drug Target Discovery
Mass Spectrometry is key technology for studying critical molecules and pathways. Defining molecular targets is crucial for the process of drug development. In our group, we are focused on using proteomics, mass spectrometry and biochemical approaches to understand disease processes.
Cellular Signalling
We aim to understand the proteins that transmit signals within the cell and the signalling pathways that regulate the cell’s functions. Understanding these pathways and proteins enables the discovery of new drug targets for treating disease.