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Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Journal article

Hassell-Hart S. et al, (2020), Organometallics, 39, 408 - 416

Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.

Journal article

Ni X. et al, (2019), ACS Med Chem Lett, 10, 1661 - 1666

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.

Journal article

Fagan V. et al, (2019), J Med Chem, 62, 9008 - 9025

Discovery of a potent and selective fragment-like inhibitor of SPIN1

Conference paper


Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

Journal article

Böttcher J. et al, (2019), Nat Chem Biol, 15, 822 - 829

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

Journal article

Resnick E. et al, (2019), J Am Chem Soc, 141, 8951 - 8968

A chemical toolbox for the study of bromodomains and epigenetic signaling.

Journal article

Wu Q. et al, (2019), Nat Commun, 10

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).

Journal article

Asquith CRM. et al, (2019), J Med Chem, 62, 2830 - 2836

Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9.

Journal article

Christott T. et al, (2019), SLAS Discov, 24, 133 - 141

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains.

Journal article

D'Ascenzio M. et al, (2019), Angew Chem Int Ed Engl, 58, 1007 - 1012

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

Journal article

Vazquez-Rodriguez S. et al, (2019), Angew Chem Int Ed Engl, 58, 515 - 519

Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).

Journal article

Heidenreich D. et al, (2018), J Med Chem, 61, 10929 - 10934

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