Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Chen Z. et al, (2025), Nat Commun, 16
Structural basis of the mechanism and inhibition of a human ceramide synthase.
Pascoa TC. et al, (2024), Nat Struct Mol Biol
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist.
Chi G. et al, (2024), Structure, 32, 1137 - 1149.e4
The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Liang Q. et al, (2024), Nat Commun, 15
Structural basis of the mechanism and inhibition of a human ceramide synthase
Pascoa TC. et al, (2023)
Structural characterization of human urea transporters UT-A and UT-B and their inhibition.
Chi G. et al, (2023), Sci Adv, 9
Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
Chi G. et al, (2022), Nat Commun, 13
Snapshots of actin and tubulin folding inside the TRiC chaperonin.
Kelly JJ. et al, (2022), Nat Struct Mol Biol, 29, 420 - 429
Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Chi G. et al, (2021), EMBO J, 40
Expression Screening of Human Integral Membrane Proteins Using BacMam.
Mahajan P. et al, (2021), Methods Mol Biol, 2199, 95 - 115
Functional similarities between heterogeneously and homogenously expressed MscL constructs.
Chi G. et al, (2015), European biophysics journal : EBJ, 44, 589 - 598
Inducible release of particulates from liposomes using the mechanosensitive channel of large conductance and L-α-lysophosphatidylcholine.
Foo A. et al, (2015), European biophysics journal : EBJ, 44, 521 - 530
Bacterial mechanosensitive channels: models for studying mechanosensory transduction.
Martinac B. et al, (2014), Antioxidants & redox signaling, 20, 952 - 969
Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site.
Manos-Turvey A. et al, (2012), Organic & biomolecular chemistry, 10, 9223 - 9236
Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
Chi G. et al, (2012), Biochemistry, 51, 4868 - 4879