CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.
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Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain.
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Driving Therapeutic Innovation in Neurodegenerative Disease with Hydrogen Deuterium eXchange Mass Spectrometry
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Characterization of ADAMTS9 proteoglycanase activity: comparison with ADAMTS1, ADAMTS4 and ADAMTS5.
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Effect of a Laparoscopic Donor Nephrectomy in Healthy Living Kidney Donors on the Acute Phase Response Using Either Propofol or Sevoflurane Anesthesia
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CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue.
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Identification of undetected SARS-CoV-2 infections by clustering of Nucleocapsid antibody trajectories.
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EAAT3 modulation: A potential novel avenue towards remyelination in multiple sclerosis.
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Integrative proximal-ubiquitomics profiling for deubiquitinase substrate discovery applied to USP30.
Damianou A. et al, (2025), Cell Chem Biol
Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma
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Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium
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MolSnapper: Conditioning Diffusion for Structure-Based Drug Design.
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Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.
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Structures of the human adult muscle-type nicotinic receptor in resting and desensitized states.
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Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
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