The promise and peril of chemical probes.
Arrowsmith CH., Audia JE., Austin C., Baell J., Bennett J., Blagg J., Bountra C., Brennan PE., Brown PJ., Bunnage ME., Buser-Doepner C., Campbell RM., Carter AJ., Cohen P., Copeland RA., Cravatt B., Dahlin JL., Dhanak D., Edwards AM., Frederiksen M., Frye SV., Gray N., Grimshaw CE., Hepworth D., Howe T., Huber KVM., Jin J., Knapp S., Kotz JD., Kruger RG., Lowe D., Mader MM., Marsden B., Mueller-Fahrnow A., Müller S., O'Hagan RC., Overington JP., Owen DR., Rosenberg SH., Roth B., Ross R., Schapira M., Schreiber SL., Shoichet B., Sundström M., Superti-Furga G., Taunton J., Toledo-Sherman L., Walpole C., Walters MA., Willson TM., Workman P., Young RN., Zuercher WJ.
Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.