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Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the kinases, ubiquitin processing and other PTM enzymes that modify NLRP3, ASC/PYCARD and caspase-1, leading to inflammasome regulation, activation and signal termination. Potential target therapeutic entry points for a number of inflammatory diseases focussed on PTM enzyme readers, writers and erasers, leading to the regulation of inflammasome function, are discussed. Video Abstract.

Original publication

DOI

10.1186/s12964-020-00688-6

Type

Journal article

Journal

Cell Commun Signal

Publication Date

24/02/2021

Volume

19

Keywords

Drug targets, NLRP3 inflammasome, Post-translational modifications, Protein interaction, Signalling