Contact information
Elisabeth Mira Rothweiler
Pharmacist, DPhil in Clinical Medicine
Mira is investigating synthetic nanobodies as ‘molecular Trojan horses’ to facilitate drug delivery to the brain across the blood brain barrier.
She is the Project Lead for the CNS shuttle project at the Oxford Drug Discovery Institute (ODDI) assay development team, and utilises ribosome- and phage-display screens in combination with biophysical and cell-based models to identify novel nanobody shuttles for the brain delivery of therapeutics for Alzheimer’s Disease.
Her postdoctoral work is funded by Alzheimer’s Research UK. She was awarded a Junior Research Fellowship from Kellogg College in 2024 and is a College Lecturer in Medicine at Hertford College. Previously, she obtained a DPhil in Clinical Medicine in the field of chemical biology and targeted protein degradation under co-supervision of Prof Paul Brennan and Dr Kilian Huber.
Mira graduated from the Ludwig Maximilian University in Munich as a licensed Pharmacist and is interested in drug discovery and the development of novel therapeutics for neurodegenerative diseases.
Recent publications
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A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.
Journal article
Rothweiler EM. et al, (2025), Nat Commun, 16
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Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors.
Journal article
Bauer LG. et al, (2025), Angew Chem Int Ed Engl, 64
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Covalent Inhibitors of KEAP1 with Exquisite Selectivity.
Journal article
Fejes I. et al, (2024), J Med Chem, 67, 21208 - 21222
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A live cell PRMT5 NanoBRET Target Engagement Assay querying competitive and uncompetitive modes of inhibition
Journal article
Michaud A. et al, (2024), CANCER RESEARCH, 84
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A live cell PRMT5 NanoBRETT target engagement assay querying competitive and uncompetitive modes of inhibition
Journal article
Teske KA. et al, (2024), MOLECULAR CANCER THERAPEUTICS, 23
