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Search results (37)

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Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain.

He H. et al, (2018), Physiol Genomics, 50, 605 - 614

PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence.

Hachem A. et al, (2017), Development, 144, 2914 - 2924

Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling.

Lin WK. et al, (2017), J Biol Chem, 292, 13243 - 13257

Ebolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes.

Simmons JA. et al, (2016), J Virol, 90, 605 - 610

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.

Capel RA. et al, (2015), J Biol Chem, 290, 30087 - 30098

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A. et al, (2015), J Biol Chem, 290, 21376 - 21392

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.

Ruas M. et al, (2015), EMBO J, 34, 1743 - 1758

Two-Pore Channels: Lessons from Mutant Mouse Models.

Ruas M. et al, (2015), Messenger (Los Angel), 4, 4 - 22

TPC: the NAADP discovery channel?

Morgan AJ. et al, (2015), Biochem Soc Trans, 43, 384 - 389

Reply to "TPC1 Knockout Knocks Out TPC1".

Ruas M. et al, (2015), Mol Cell Biol, 35

Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca(2+) signaling during myogenesis in intact zebrafish.

Kelu JJ. et al, (2015), Int J Dev Biol, 59, 313 - 325

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.

Favia A. et al, (2014), Proc Natl Acad Sci U S A, 111, E4706 - E4715

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.

Ruas M. et al, (2014), Mol Cell Biol, 34, 3981 - 3992

Synthesis of NAADP-AM as a membrane-permeant NAADP analog.

Galione A. et al, (2014), Cold Spring Harb Protoc, 2014

Measurement of luminal pH of acidic stores as a readout for NAADP action.

Galione A. et al, (2014), Cold Spring Harb Protoc, 2014

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