Synthesis of NAADP-AM as a membrane-permeant NAADP analog.

Galione A., Chuang K-T., Funnell TM., Davis LC., Morgan AJ., Ruas M., Parrington J., Churchill GC.

Nicotinic acid adenine dinucleotide phosphate (NAADP), like the other major messengers for Ca²⁺ mobilization, is passively membrane-impermeant. Instead, a cell-permeant acetoxymethyl ester derivative of NAADP (NAADP-AM) can be synthesized as described here and used to study NAADP-mediated Ca²⁺ release.

DOI

10.1101/pdb.prot076927

Type

Journal article

Publication Date

2014-10-01T00:00:00+00:00

Volume

2014

Keywords

Animals, Calcium, Calcium Signaling, Cells, Cultured, Humans, NADP, Permeability

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