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A multi-disciplinary Institute within the University of Oxford which focuses upon translational activities to catalyse the discovery of new medicines.

Publications

Rational discovery of therapeutic PAK1 allosteric activators.

He Y. et al, (2026), Cell

Symptom Duration-Dependent Protein Abundance Changes in Symptomatic and Asymptomatic Tendons in Early Stage Unilateral Patellar Tendinopathy.

Steffen D. et al, (2026), J Proteome Res

Refined USP25/28 inhibitors with improved selectivity towards c-Myc driven squamous lung cancer cells

Pinto-Fernández A. et al, (2026)

Proteomic Snapshots of Structural Cross-Linking Rearrangements in Ca2+/Calmodulin-Dependent Kinase-1-Delta Associated with Its Regulation by ATP, Ca2+/Calmodulin, and Reduction Potential.

Mbabala L. et al, (2026), J Proteome Res

Protocol for stable cell line production to express muscle-type nicotinic receptor.

Li A. et al, (2026), STAR Protoc, 7

Expanding the genotypic spectrum of combined oxidative phosphorylation deficiency 54.

Lai KL. et al, (2026), Neurogenetics, 27

5,10-Methylenetetrahydrofolate Reductase─the Key Allosteric Regulator in One-Carbon Metabolism.

Blomgren LKM. et al, (2026), Biochemistry

A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery Data.

MacDermott-Opeskin H. et al, (2026), J Chem Inf Model

Experiences of participant engagement from an African and Asian ancestry cohort during a clinical research study of lymph node responses to influenza immunisation in the United Kingdom

Metcalf D. et al, (2026)

Spatial protein expression patterns across pathologically-associated fibers revealed molecular specialization in inclusion body myositis.

Nijssen TI. et al, (2026), Cell Commun Signal

Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus.

Ye M. et al, (2026), Nat Commun

The Heterocycle Isostere Explorer: A Computational Tool for the Discovery of Novel Aromatic Heterocyclic Isosteres.

Holland MTO. et al, (2026), J Med Chem

Circulating TNFα in deceased donors promotes kidney injury and associates with inferior short- and long-term graft function and survival.

Fawaz S. et al, (2026), Am J Transplant

Kidney Metabolism During Normothermic Machine Perfusion Differs Substantially From In Vivo Conditions.

Ogurlu B. et al, (2026), Transplantation, 110, e405 - e415

Pervasive phenotypic effects of FBXO42 are promoted by regulation of PP4 phosphatase.

Yang H. et al, (2026), EMBO J, 45, 1332 - 1361

Assessing Aβ-independent effects of Module 42 on immune function in vitro.

Ajith I. et al, (2026), Alzheimers Dement, 22

Multi-omics analysis of a pig-to-human decedent kidney xenotransplant.

Schmauch E. et al, (2026), Nature, 650, 205 - 217

Analytical challenges for mapping non-canonical and non-protein ubiquitin/Ubl modifications by mass spectrometry.

Kessler BM., (2026), Expert Rev Proteomics, 1 - 7

Separate transcription and splicing gene networks are linked and coordinated by the pRb-E2F pathway.

Carr SM. et al, (2026), Nucleic Acids Res, 54

Tetraspanin-based immunocapture for high-depth proteomic profiling of extracellular vesicles from cerebrospinal fluid for biomarker discovery.

Dellar ER. et al, (2026), Clin Proteomics, 23

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