Centre for Medicines Discovery (CMD)

Carbamoyl fluorides as serine hydrolase inhibitors: a case study on FphI from Staphylococcus aureus

Randall G. et al, (2026), Bioorganic Chemistry, 176, 109834 - 109834

A comprehensive pharmacological survey across heterogeneous patient-derived glioblastoma stem cell models

Elliott RJR. et al, (2026), Iscience, 29

Multidimensional proteomics and explainable AI feature selection identify cross-platform lung cancer molecular signature in blood plasma.

Gushterov N. et al, (2026), Commun Med (Lond)

Inhibition of MLLT1 limits growth of KMT2A::AFF1 leukaemias without killing healthy haematopoietic stem cells.

Rajhansa S. et al, (2026), Exp Hematol

Nucleophagy removes cytotoxic trapped PARP1.

Hoslett G. et al, (2026), Nat Cell Biol

Urine Recirculation During Normothermic Kidney Preservation Improves Energy Balance Involving the Urea and Citric Acid Cycles.

Weissenbacher A. et al, (2026), Transplant Direct, 12

Structural insights into cobalamin loading and reactivation of human methionine synthase.

Ferreira DSM. et al, (2026), Nat Commun

An Explainable Deep Learning Framework for Imaging Genetics: Deriving Brain-Genotype Scores From MRI to Link Genetic Variation, Brain Structure, and Cognition

Alhasani KT. et al, (2026)

Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome.

Koprulu M. et al, (2026), Cell

Targeting Activin Receptor-like Kinase 2 Using Heterobifunctional Protein Degraders.

Webb DT. et al, (2026), J Med Chem

DNA-induced conformational changes in SPRTN relieve its auto-inhibitory effect on protease activity.

Song W. et al, (2026), bioRxiv

Discovery and Characterization of a Nonacidic Small-Molecule Inhibitor of the Sodium-Coupled Dicarboxylate Transporter NaCT.

Quigley A. et al, (2026), J Med Chem

K63-linked ubiquitylation of S2P-RNAPII regulates transcription in a DNAPK inter-dependent manner in response to double-strand breaks.

Pantazi V. et al, (2026), Nucleic Acids Res, 54

Pleural fluid neutrophil extracellular traps are associated with disease severity and risk of one-year mortality in pleural infection. An observational, international, multicohort study (TORPIDS-3).

Chu JY. et al, (2026), Eur Respir J

Targeted Intracellular Delivery of Amino Acids to Trophoblast Cells Reveals Proteomic Signatures of Cellular Utilisation.

Mazey E. et al, (2026), Biomolecules, 16

SPNS2 exports sphingosine-1-phosphate and imports glucose.

Weigel C. et al, (2026), Nat Commun

KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9.

Belle R. et al, (2026), Nat Chem

iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria.

Diotallevi M. et al, (2026), Nat Metab

Ugi-Tetrazole-Derived α‑Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV‑2 3CLpro.

van der Straat R. et al, (2026), ACS Med Chem Lett, 17, 856 - 865

Symptom Duration-Dependent Protein Abundance Changes in Symptomatic and Asymptomatic Tendons in Early Stage Unilateral Patellar Tendinopathy.

Steffen D. et al, (2026), J Proteome Res, 25, 2170 - 2182

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