Centre for Medicines Discovery (CMD)

Targeted Intracellular Delivery of Amino Acids to Trophoblast Cells Reveals Proteomic Signatures of Cellular Utilisation

Mazey E. et al, (2026), Biomolecules, 16, 628 - 628

SPNS2 exports sphingosine-1-phosphate and imports glucose.

Weigel C. et al, (2026), Nat Commun

KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9.

Belle R. et al, (2026), Nat Chem

iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria.

Diotallevi M. et al, (2026), Nat Metab

Ugi-Tetrazole-Derived α‑Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV‑2 3CLpro.

van der Straat R. et al, (2026), ACS Med Chem Lett, 17, 856 - 865

Symptom Duration-Dependent Protein Abundance Changes in Symptomatic and Asymptomatic Tendons in Early Stage Unilateral Patellar Tendinopathy.

Steffen D. et al, (2026), J Proteome Res, 25, 2170 - 2182

Proteomic Snapshots of Structural Cross-Linking Rearrangements in Ca2+/Calmodulin-Dependent Kinase-1-Delta Associated with Its Regulation by ATP, Ca2+/Calmodulin, and Reduction Potential.

Mbabala L. et al, (2026), J Proteome Res, 25, 1914 - 1928

Molecular architecture of Influenza A virions.

Vijayakrishnan S. et al, (2026)

Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles.

Karabova MK. et al, (2026), Alzheimers Dement, 22

Rational discovery of therapeutic PAK1 allosteric activators.

He Y. et al, (2026), Cell

Protocol for stable cell line production to express muscle-type nicotinic receptor.

Li A. et al, (2026), STAR Protoc, 7

The E3-ome gene-centric compendium reveals the human E3 ligase landscape.

Chua NK. et al, (2026), Cell

Refined USP25/28 inhibitors with improved selectivity towards c-Myc driven squamous lung cancer cells

Pinto-Fernández A. et al, (2026)

Expanding the genotypic spectrum of combined oxidative phosphorylation deficiency 54.

Lai KL. et al, (2026), Neurogenetics, 27

5,10-Methylenetetrahydrofolate Reductase─the Key Allosteric Regulator in One-Carbon Metabolism.

Blomgren LKM. et al, (2026), Biochemistry

The Heterocycle Isostere Explorer: A Computational Tool for the Discovery of Novel Aromatic Heterocyclic Isosteres.

Holland MTO. et al, (2026), J Med Chem, 69, 4408 - 4423

A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery Data.

MacDermott-Opeskin H. et al, (2026), J Chem Inf Model

Experiences of participant engagement from an African and Asian ancestry cohort during a clinical research study of lymph node responses to influenza immunisation in the United Kingdom

Metcalf D. et al, (2026)

Spatial protein expression patterns across pathologically-associated fibers revealed molecular specialization in inclusion body myositis.

Nijssen TI. et al, (2026), Cell Commun Signal, 24

Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus.

Ye M. et al, (2026), Nat Commun, 17

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