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Search results (137)

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The E3-ome gene-centric compendium reveals the human E3 ligase landscape.

Chua NK. et al, (2026), Cell

Ubiquitin E3 ligase KLHL6 brings exhausted T-cells back into action.

Chen Z. et al, (2026), Immun Inflamm, 2

Fragment-Based Drug Discovery of Novel High-affinity, Selective, and Anti-inflammatory Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction.

Lin C. et al, (2025), Angew Chem Int Ed Engl, 64

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.

Chen Z. et al, (2025), Nat Commun, 16

Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.

Tredup C. et al, (2025), RSC Med Chem, 16, 457 - 464

Covalent Inhibitors of KEAP1 with Exquisite Selectivity.

Fejes I. et al, (2024), J Med Chem, 67, 21208 - 21222

Structure-Guided Conformational Restriction Leading to High-Affinity, Selective, and Cell-Active Tetrahydroisoquinoline-Based Noncovalent Keap1-Nrf2 Inhibitors.

Qin Y. et al, (2024), J Med Chem, 67, 18828 - 18864

A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1.

Pinkas DM. et al, (2024), Structure, 32, 1586 - 1593.e4

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.

Němec V. et al, (2024), J Med Chem, 67, 12632 - 12659

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.

Bashore FM. et al, (2024), ACS Med Chem Lett, 15, 1325 - 1333

A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1

Pinkas DM. et al, (2024)

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.

Bashore FM. et al, (2024)

BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.

Miller KA. et al, (2024), J Med Genet, 61, 490 - 501

Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays.

van Veggel L. et al, (2024), ACS Chem Neurosci, 15, 1424 - 1431

Discovery of Conformationally Constrained ALK2 Inhibitors.

González-Álvarez H. et al, (2024), J Med Chem, 67, 4707 - 4725

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