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Search results (86)

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Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK Inhibitors.

Baldwin AG. et al, (2025), J Med Chem, 68, 17427 - 17456

Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.

Baldwin AG. et al, (2025), J Med Chem, 68, 719 - 752

Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.

de Souza Gama FH. et al, (2024), J Med Chem, 67, 8609 - 8629

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.

Balıkçı E. et al, (2024), J Med Chem, 67, 7245 - 7259

Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.

Henderson SH. et al, (2024), Eur J Med Chem, 269

Recent advances in the structural biology of tyrosine kinases.

Rygiel KA. and Elkins JM., (2023), Curr Opin Struct Biol, 82

Updated protein domain annotation of the PARP protein family sheds new light on biological function.

Suskiewicz MJ. et al, (2023), Nucleic Acids Res, 51, 8217 - 8236

Target 2035 - an update on private sector contributions.

Ackloo S. et al, (2023), RSC Med Chem, 14, 1002 - 1011

An open source plant kinase chemogenomics set.

Ercoli MF. et al, (2022), Plant Direct, 6

Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity.

Collins R. et al, (2022), J Med Chem, 65, 13705 - 13713

Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.

Scott F. et al, (2022), Bioorg Med Chem Lett, 60

Chemical Probes for Understudied Kinases: Challenges and Opportunities.

Serafim RAM. et al, (2022), J Med Chem, 65, 1132 - 1170

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.

Serafim RAM. et al, (2021), J Med Chem, 64, 13259 - 13278

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.

Henderson SH. et al, (2021), J Med Chem, 64, 11709 - 11728

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.

Berger B-T. et al, (2021), Cell Chem Biol, 28, 686 - 698.e7

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