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Search results (116)

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Advances in BRET probes for intracellular target engagement studies.

Capener JL. et al, (2026), Nat Chem Biol

A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis.

Nguyen T-A. et al, (2025), Science, 390, 1143 - 1150

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.

Rothweiler EM. et al, (2025), Nat Commun, 16

Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in Escherichia coli

Seow TCY. et al, (2025)

Pharmacological targeting of BMAL1 modulates circadian and immune pathways.

Pu H. et al, (2025), Nat Chem Biol, 21, 736 - 745

Drug repurposing in amyotrophic lateral sclerosis (ALS).

Carroll E. et al, (2025), Expert Opin Drug Discov, 20, 447 - 464

Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence.

Lu J. et al, (2025)

Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.

Tredup C. et al, (2025), RSC Med Chem, 16, 457 - 464

Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors.

Bauer LG. et al, (2025), Angew Chem Int Ed Engl, 64

Covalent Inhibitors of KEAP1 with Exquisite Selectivity.

Fejes I. et al, (2024), J Med Chem, 67, 21208 - 21222

Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300.

Chen X. et al, (2024), JACS Au, 4, 3094 - 3103

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response.

Lee AA. et al, (2024)

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.

Balıkçı E. et al, (2024), J Med Chem, 67, 7245 - 7259

Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.

Raux B. et al, (2024), Bioorg Med Chem Lett, 98

Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.

Digles D. et al, (2024), Front Pharmacol, 15

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