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Search results (128)

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Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response.

Marques A-SMC. et al, (2026), Nat Commun

Therapeutic targeting of SETD2-deficient cancer cells with the small-molecule compound RITA

Humphrey T. et al, (2026)

Advances in BRET probes for intracellular target engagement studies.

Capener JL. et al, (2026), Nat Chem Biol

Leveraging E2 ligases for induced proximity and modulation of novel cancer-relevant targets and neosubstrates

Chen X. et al, (2026), CANCER RESEARCH, 86

A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis.

Nguyen T-A. et al, (2025), Science, 390, 1143 - 1150

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.

Rothweiler EM. et al, (2025), Nat Commun, 16

Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in Escherichia coli

Seow TCY. et al, (2025)

Pharmacological targeting of BMAL1 modulates circadian and immune pathways.

Pu H. et al, (2025), Nat Chem Biol, 21, 736 - 745

Drug repurposing in amyotrophic lateral sclerosis (ALS).

Carroll E. et al, (2025), Expert Opin Drug Discov, 20, 447 - 464

Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence.

Lu J. et al, (2025)

Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity

Marques A-SMC. et al, (2025)

Functional profiling reveals a non-enzymatic role of NUDT5 in repressing purine de novo synthesis

Lin J-MG. et al, (2025)

Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.

Tredup C. et al, (2025), RSC Med Chem, 16, 457 - 464

Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors.

Bauer LG. et al, (2025), Angew Chem Int Ed Engl, 64

A Live Cell BRET Probe to Quantify PRMT5-MTA Uncompetitive Target Engagement

Rothweiler E. et al, (2025)

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