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Search results (16)

« Back to Publications

Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography.

Grosjean H. et al, (2025), Angew Chem Int Ed Engl, 64

The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures.

Bradshaw WJ. et al, (2024), Structure, 32, 2337 - 2351.e4

Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.

Bradshaw WJ. et al, (2024), Structure, 32, 453 - 466.e6

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.

Bashore FM. et al, (2024), PLoS One, 19

Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.

Du Y. et al, (2023), J Biol Chem, 299

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

Barrett JR. et al, (2023)

Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2

Bradshaw WJ. et al, (2023)

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.

Bashore FM. et al, (2023), bioRxiv

Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile.

Bradshaw WJ. et al, (2019), J Biol Chem, 294, 15850 - 15861

The structure of the S-layer of Clostridium difficile.

Bradshaw WJ. et al, (2018), J Cell Commun Signal, 12, 319 - 331

The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile.

Bradshaw WJ. et al, (2017), FEBS J, 284, 4343 - 4357

Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro.

Bradshaw WJ. et al, (2017), FEBS J, 284, 2886 - 2898

Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.

Bradshaw WJ. et al, (2017), Sci Rep, 7

Molecular features of the sortase enzyme family.

Bradshaw WJ. et al, (2015), FEBS J, 282, 2097 - 2114

Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide.

Bradshaw WJ. et al, (2015), Acta Crystallogr F Struct Biol Commun, 71, 295 - 303

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