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Search results (59)

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Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts.

Ye M. et al, (2025), ACS Cent Sci, 11, 2385 - 2399

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Herasymenko O. et al, (2025), J Chem Inf Model, 65, 6884 - 6898

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks.

Song W. et al, (2025), Nucleic Acids Res, 53

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.

Newman JA. et al, (2025), Nat Commun, 16

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks.

Song W. et al, (2024)

Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing.

Roddan R. et al, (2024)

SNM1A is crucial for efficient repair of complex DNA breaks in human cells.

Swift LP. et al, (2024), Nat Commun, 15

Structures of the human transcription factor brachyury offer insights into DNA recognition, and identify small molecule binders for the development of degraders for cancer therapy

Newman JA. et al, (2024)

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target.

Bielinski M. et al, (2024), Chem Sci, 15, 8227 - 8241

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.

Syed A. et al, (2023), Nucleic Acids Res, 51, 9920 - 9937

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.

Imprachim N. et al, (2023), Nucleic Acids Res, 51, 475 - 487

SNM1A (DCLRE1A) is crucial for efficient repair of complex DNA breaks in human cells

McHugh P. et al, (2023)

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

Ye M. et al, (2022)

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development

Imprachim N. et al, (2022)

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.

Rota IA. et al, (2021), Sci Adv, 7

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