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Search results (49)

« Back to Publications

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.

Ni X. et al, (2025)

Fragmenstein: predicting protein-ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding-based methodology.

Ferla MP. et al, (2025), J Cheminform, 17

Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency.

Blanco E. et al, (2025), J Exp Med, 222

Crystal structure of Fatty Acid Thioesterase A bound by 129 fragments provides diverse development opportunities

Kot E. et al, (2024)

De novo variants in DENND5B cause a neurodevelopmental disorder.

Scala M. et al, (2024), Am J Hum Genet, 111, 529 - 543

Fragmenstein: predicting protein-ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology

Ferla MP. et al, (2024)

Enabling equitable and affordable access to novel therapeutics for pandemic preparedness and response via creative intellectual property agreements.

Griffen EJ. et al, (2024), Wellcome Open Res, 9

Biallelic MED27 variants lead to variable ponto-cerebello-lental degeneration with movement disorders.

Maroofian R. et al, (2023), Brain, 146, 5031 - 5043

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.

Boby ML. et al, (2023), Science, 382

Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases.

Pagnamenta AT. et al, (2023), Genome Med, 15

The prevalence and phenotypic range associated with biallelic PKDCC variants.

Pagnamenta AT. et al, (2023), Clin Genet, 104, 121 - 126

Turning high-throughput structural biology into predictive inhibitor design.

Saar KL. et al, (2023), Proc Natl Acad Sci U S A, 120

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.

Gahbauer S. et al, (2023), Proc Natl Acad Sci U S A, 120

Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities.

Cali E. et al, (2023), Genet Med, 25, 135 - 142

Variable skeletal phenotypes associated with biallelic variants in PRKG2.

Pagnamenta AT. et al, (2022), J Med Genet, 59, 947 - 950

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